Axonal mRNA translation in neurological disorders
نویسندگان
چکیده
منابع مشابه
Stem Cell Therapy in Pediatric Neurological Disorders
Pediatric neurological disorders including muscular dystrophy, cerebral palsy, and spinal cord injury are defined as a heterogenous group of diseases, of which some are known to be genetic. The two significant features represented for stem cells, leading to distinguish them from other cell types are addressed as below: they can renew themselves besides the ability to differentiate into cells wi...
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mRNA of opioid receptor (KOR) can be transported to nerve fibers, including axons of dorsal root ganglia (DRG), and can be locally translated. Yeast three-hybrid screening identifies Copb1 as a kor mRNA-associated protein that form complexes with endogenous kor mRNA, which are colocalized in the soma and axons of DRG neurons. Axonal transport of kor mRNA is demonstrated, directly, by observing ...
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Disruptions to neuronal mRNA translation are hypothesized to underlie human neurodevelopmental syndromes. Notably, the mRNA translation re-initiation factor DENR is a regulator of eukaryotic translation and cell growth, but its mammalian functions are unknown. Here, we report that Denr influences the migration of murine cerebral cortical neurons in vivo with its binding partner Mcts1, whereas p...
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Pregnant women can present with a wide variety of neurological conditions. Patient data from 1 January 1985 through 31 December 1994 for all deliveries at the Tsan Yuk and Queen Mary hospitals were reviewed to determine the local frequency of various neurological conditions during pregnancy. Conditions including epilepsy, eclampsia, facial nerve palsy, pituitary tumour, cerebrovascular disorder...
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Neurological disorders are a significant cause of morbidity and mortality in pregnancy. In the UK between 2003 and 2005, women with neurological conditions accounted for 37 out of a total 87 ‘indirect’ maternal deaths (those not arising from pregnancy or birth), with stroke (n = 24) and epilepsy (n =11)1 accounting for the majority of deaths from neurological causes2. Neurological assessment ca...
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ژورنال
عنوان ژورنال: RNA Biology
سال: 2020
ISSN: 1547-6286,1555-8584
DOI: 10.1080/15476286.2020.1822638